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doi: 10.1038/nrn.2017.128 150 MicuI.PlemelJ

Important safety warnings seek urgent medical attention if you experience: Severe or persistent abdominal pain, which may radiate to the back this could indicate pancreatitis , a serious but rare risk associated with GLP-1based therapies as a class [16] [17] Right upper quadrant pain, fever, or jaundice these may suggest gallbladder disease , another class-associated risk Signs of dehydration (dizziness, reduced urine output, extreme thirst) resulting from severe vomiting or diarrhoea, which can affect kidney function Pregnancy and breastfeeding: Use of GLP-1based therapies and related investigational agents is not recommended during pregnancy or breastfeeding

By strengthening the skins natural defense layer, niacinamide helps retain moisture and block out external irritants

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Human studies (in-vivo) using GHK-Cu creams have reported visible improvements to skin density, elasticity, and wrinkle depth after several weeks of use